RETA-3 30mg

RETA-3 30mg is a 30mg vial of RETA-3 (retatrutide), a GIP, GLP-1 and glucagon receptor agonist, supplied as freeze-dried powder. It’s for in-vitro and lab research only.

RETA-3 is our code name for retatrutide. The compound inside the vial is retatrutide, and everything below describes it.

RETA-3 (retatrutide) at a glance

Retatrutide (LY3437943) is a single 39-amino-acid peptide from Eli Lilly that acts on three receptors at once: GIP, GLP-1 and glucagon. That makes it the first triple hormone receptor agonist to reach late-stage trials.

A fatty acid side chain lets it bind albumin in the blood, which stretches its half-life to about six days and makes once-weekly study possible. It isn’t approved anywhere yet.

How RETA-3 works

Retatrutide hits three receptors with one peptide: GIP, GLP-1 and glucagon. The first two are incretins that boost glucose-dependent insulin release and, in GLP-1’s case, curb appetite and slow stomach emptying.

The glucagon part is the unusual bit. Glucagon raises energy expenditure and pushes the liver to burn fat, so pairing it with the incretins is meant to work on both sides of energy balance. That’s the main reason researchers compare it with the dual and single agonists.

RETA-3 30mg specifications

• Compound: RETA-3 (retatrutide)
• Also known as: LY3437943
• CAS number: 2381089-83-2
• Molar mass: 4,731.3 g/mol
• Structure: 39 amino acids with a fatty diacid side chain
• Amount: 30mg per vial
• Form: lyophilized (freeze-dried) powder
• Label: compound name and amount printed on every unit
• SKU: RETA3-30
• Use: laboratory research only

RETA-3 research

Jastreboff and colleagues reported the phase 2 obesity trial in the New England Journal of Medicine in 2023. At the highest dose, average weight loss reached 24.2% at 48 weeks, the largest figure any incretin compound had shown at that stage.

A substudy in Nature Medicine (Sanyal and colleagues, 2024) found large drops in liver fat, and a separate phase 2 trial in type 2 diabetes was published in The Lancet in 2023. Lilly’s phase 3 TRIUMPH program is testing it in obesity, diabetes, knee osteoarthritis and sleep apnea.

To read the papers yourself, start with this PubMed search for Retatrutide.

RETA-3 compared with similar compounds

RETA-3 30mg is easier to place once you see it next to the compounds it’s usually compared with. RETA-3 hits GLP-1, GIP and glucagon receptors, the triple agonist with the biggest phase 2 numbers so far. The others:

• SEMA-1 acts on the GLP-1 receptor only and lasts about a week, the most studied compound in the group
• TIRZ-2 adds GIP receptor activity to GLP-1, a dual agonist with larger weight effects than semaglutide in trials
• Survodutide is another GLP-1 and glucagon dual agonist, in phase 3 for obesity and the liver disease MASH
• CAG-4 works through amylin receptors instead of incretins, often studied next to or with semaglutide

The main difference between these compounds is which receptors they hit. Pick the one that matches the receptor question in your study, and use the others as comparisons. See them all on our GLP-1 peptides page.

RETA-3 30mg reconstitution and concentration

Concentration is the amount in the vial divided by the volume of water you add. With 30mg of powder in this vial:

• 2mL of bacteriostatic water gives 15mg/mL
• 3mL of bacteriostatic water gives 10mg/mL
• 5mL of bacteriostatic water gives 6mg/mL

Pick the volume that keeps your own calculations simple, then write the concentration and the mixing date on the label.

Most labs use sterile bacteriostatic water. We stock bacteriostatic water in 3mL, 10mL and 30mL sizes. Warm the sealed vial to room temperature, add the water slowly along the glass wall and swirl gently until it’s clear. Never shake it.

How to store RETA-3 30mg

The dry powder keeps best cold and dark. A freezer at -20°C is right for long-term storage. After reconstitution, store it in the fridge at 2 to 8°C and finish it within roughly four weeks.

Leave sealed vials sealed until you need them. Dry powder in a closed vial lasts far longer than solution, so there’s no reason to mix more than one at a time.

RETA-3 30mg quality and handling

Every RETA-3 30mg vial carries a printed label with the compound name and amount, so you always know what you’re holding. If your lab needs batch paperwork for its records, contact Peptira support before you order and ask what’s available for the current batch.

Labs that check material in-house normally confirm identity with mass spectrometry, which checks the molecular weight, and measure purity with HPLC, which separates the main compound from anything else in the sample.

If you run a long study, try to order everything you need at once and log it when it arrives. It removes one variable from your results.

Choosing an RETA-3 strength

• RETA-3 10mg: $99.00, about $9.90 per mg
• RETA-3 20mg: $139.00, about $6.95 per mg
• RETA-3 30mg (this page): $179.00, about $5.97 per mg

RETA-3 30mg is one of the larger sizes, and bigger vials usually cost less per milligram. It suits longer studies where you’d otherwise reorder.

Often ordered with RETA-3 30mg

• TIRZ-2 20mg, a GIP/GLP-1 agonist
• Survodutide 10mg, a GLP-1/glucagon agonist
• SEMA-1 10mg, a GLP-1 agonist
• CAG-4 10mg, an amylin analog
• SLU-PP-332 BAM-15 Capsules, a capsule format

Browse the full GLP-1 peptides and weight loss peptides range, see every vial on our research peptides page or head back to the Peptira home page.

Common questions about RETA-3 30mg

How much is in the RETA-3 30mg vial?

30mg of freeze-dried powder. The amount is printed on the label.

What is RETA-3?

RETA-3 is our catalog name for retatrutide. The vial holds retatrutide as freeze-dried powder.

Where can I buy RETA-3 30mg?

Right here at Peptira. Add RETA-3 30mg to the cart on this page and it ships free worldwide.

What do I mix RETA-3 30mg with?

Sterile bacteriostatic water is the usual choice. The reconstitution section above shows the concentration for each volume.

How should I store it?

Keep sealed vials in the freezer at -20°C. Once mixed, refrigerate at 2 to 8°C and use within about 28 days.

Buy RETA-3 30mg from Peptira

Order RETA-3 30mg now for $179.00. It’s in stock, code PEPTIRA10 takes 10% off at checkout, and we ship free to the US, Canada, Europe and Australia. Choose crypto at checkout for an extra discount.

Need more for the same project? See the rest of our GLP-1 peptides and weight loss peptides, or go back to the Peptira home page.

For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.