RETA-3 10mg

RETA-3 10mg from Peptira is 10mg of RETA-3 (retatrutide) in a sealed glass vial. RETA-3 is a GIP, GLP-1 and glucagon receptor agonist. It’s for in-vitro and lab research only.

RETA-3 is our code name for retatrutide. The compound inside the vial is retatrutide, and everything below describes it.

About RETA-3 (retatrutide)

Retatrutide (LY3437943) is a single 39-amino-acid peptide from Eli Lilly that acts on three receptors at once: GIP, GLP-1 and glucagon. That makes it the first triple hormone receptor agonist to reach late-stage trials.

A fatty acid side chain lets it bind albumin in the blood, which stretches its half-life to about six days and makes once-weekly study possible. It isn’t approved anywhere yet.

How RETA-3 works

Retatrutide hits three receptors with one peptide: GIP, GLP-1 and glucagon. The first two are incretins that boost glucose-dependent insulin release and, in GLP-1’s case, curb appetite and slow stomach emptying.

The glucagon part is the unusual bit. Glucagon raises energy expenditure and pushes the liver to burn fat, so pairing it with the incretins is meant to work on both sides of energy balance. That’s the main reason researchers compare it with the dual and single agonists.

RETA-3 10mg product details

• Compound: RETA-3 (retatrutide)
• Also known as: LY3437943
• CAS number: 2381089-83-2
• Molar mass: 4,731.3 g/mol
• Structure: 39 amino acids with a fatty diacid side chain
• Amount: 10mg per vial
• Form: lyophilized (freeze-dried) powder
• Label: compound name and amount printed on every unit
• SKU: RETA3-10
• Use: laboratory research only

RETA-3 research

Jastreboff and colleagues reported the phase 2 obesity trial in the New England Journal of Medicine in 2023. At the highest dose, average weight loss reached 24.2% at 48 weeks, the largest figure any incretin compound had shown at that stage.

A substudy in Nature Medicine (Sanyal and colleagues, 2024) found large drops in liver fat, and a separate phase 2 trial in type 2 diabetes was published in The Lancet in 2023. Lilly’s phase 3 TRIUMPH program is testing it in obesity, diabetes, knee osteoarthritis and sleep apnea.

The primary literature is on PubMed, run by the US National Library of Medicine. Here’s a search for Retatrutide studies to start from.

RETA-3 compared with similar compounds

Here’s how RETA-3 10mg fits among related compounds. RETA-3 hits GLP-1, GIP and glucagon receptors, the triple agonist with the biggest phase 2 numbers so far. By comparison:

• SEMA-1 acts on the GLP-1 receptor only and lasts about a week, the most studied compound in the group
• TIRZ-2 adds GIP receptor activity to GLP-1, a dual agonist with larger weight effects than semaglutide in trials
• Survodutide is another GLP-1 and glucagon dual agonist, in phase 3 for obesity and the liver disease MASH
• CAG-4 works through amylin receptors instead of incretins, often studied next to or with semaglutide

The main difference between these compounds is which receptors they hit. Pick the one that matches the receptor question in your study, and use the others as comparisons. See them all on our GLP-1 peptides page.

RETA-3 10mg quality notes

Every RETA-3 10mg vial carries a printed label with the compound name and amount, so you always know what you’re holding. If your lab needs batch paperwork for its records, contact Peptira support before you order and ask what’s available for the current batch.

Labs that check material in-house normally confirm identity with mass spectrometry, which checks the molecular weight, and measure purity with HPLC, which separates the main compound from anything else in the sample.

Write the order date and the vial details into your lab notes. If a result looks odd later, you can tie it back to the exact material you used.

Reconstituting RETA-3 10mg

The amount of liquid you add sets the concentration. For a vial holding 10mg:

• 1mL of bacteriostatic water gives 10mg/mL
• 2mL of bacteriostatic water gives 5mg/mL
• 3mL of bacteriostatic water gives 3.33mg/mL

Choose the volume that suits your measurements. Mark the vial with the concentration and date so nobody has to guess later.

Bacteriostatic water is the usual choice, and acetic acid helps with peptides that won’t dissolve in water alone. Add it slowly so it runs down the side of the vial, then swirl or roll until everything dissolves. Shaking can shear peptide chains. Skip it.

Storing RETA-3 10mg

Freeze-dried RETA-3 10mg handles room temperature fine during shipping, but for anything longer keep it in a freezer at -20°C, away from light. Once mixed, keep it in the fridge at 2 to 8°C and use it within about four weeks.

Let a frozen vial warm up to room temperature before you open it. Cold glass pulls moisture out of the air, and moisture is what degrades dry peptide.

Other RETA-3 strengths

• RETA-3 10mg (this page): $99.00, about $9.90 per mg
• RETA-3 20mg: $139.00, about $6.95 per mg
• RETA-3 30mg: $179.00, about $5.97 per mg

RETA-3 10mg is the entry size, handy when you only need a little or want to try RETA-3 before committing to a bigger vial.

Often ordered with RETA-3 10mg

• CAG-4 10mg, an amylin analog
• Survodutide 10mg, a GLP-1/glucagon agonist
• TIRZ-2 10mg, a GIP/GLP-1 agonist
• SEMA-1 20mg, a GLP-1 agonist
• L-Carnitine 10mL, a ready-made liquid vial

Browse the full GLP-1 peptides and weight loss peptides range, see every vial on our research peptides page or head back to the Peptira home page.

RETA-3 10mg questions

How much is in the RETA-3 10mg vial?

10mg of freeze-dried powder. The amount is printed on the label.

What is RETA-3?

RETA-3 is our catalog name for retatrutide. The vial holds retatrutide as freeze-dried powder.

Is RETA-3 10mg in stock?

Yes. RETA-3 10mg is in stock and ready to ship.

Where can I buy RETA-3 10mg?

Right here at Peptira. Add RETA-3 10mg to the cart on this page and it ships free worldwide.

What do I mix RETA-3 10mg with?

Sterile bacteriostatic water is the usual choice. The reconstitution section above shows the concentration for each volume.

Order RETA-3 10mg today

Ready to order? This vial costs $99.00 and is in stock. Use code PEPTIRA10 for 10% off, pay with crypto for a further discount, and shipping costs nothing wherever you are.

Need more for the same project? See the rest of our GLP-1 peptides and weight loss peptides, or go back to the Peptira home page.

For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.