SEMA-1 20mg

Our SEMA-1 20mg vial holds 20mg of lyophilized SEMA-1 (semaglutide), a GLP-1 receptor agonist. It’s for in-vitro and lab research only.

SEMA-1 is our code name for semaglutide. The compound inside the vial is semaglutide, and everything below describes it.

SEMA-1 (semaglutide) at a glance

Semaglutide is a GLP-1 receptor agonist from Novo Nordisk. It’s 94% identical to human GLP-1, with two changes that matter: an amino acid swap at position 8 that blocks the enzyme DPP-4, and a C18 fatty diacid chain that binds albumin. Together they take the half-life from about two minutes to about a week.

It’s approved as Ozempic and Rybelsus for type 2 diabetes and as Wegovy for weight management, which makes it the most studied compound in the GLP-1 class.

How SEMA-1 acts in the lab

GLP-1 is a gut hormone released after a meal. It tells the pancreas to release insulin, but only when blood sugar is high, and it slows how fast the stomach empties. Receptors in the hypothalamus pick it up too, which is where its effect on appetite comes from.

Natural GLP-1 is broken down by the enzyme DPP-4 within a couple of minutes. Semaglutide swaps one amino acid to resist DPP-4 and carries a fatty acid that binds albumin in the blood. Together those changes stretch its half-life to about a week, which is why it’s studied as a once-weekly compound.

SEMA-1 20mg specifications

• Compound: SEMA-1 (semaglutide)
• CAS number: 910463-68-2
• Molecular formula: C187H291N45O59
• Molar mass: 4,113.6 g/mol
• Structure: 31 amino acids with a C18 fatty diacid side chain
• Amount: 20mg per vial
• Form: lyophilized (freeze-dried) powder
• Label: compound name and amount printed on every unit
• SKU: SEMA1-20
• Use: laboratory research only

Published SEMA-1 studies

The STEP 1 trial (Wilding and colleagues, New England Journal of Medicine, 2021) reported average weight loss of 14.9% at 68 weeks against 2.4% on placebo.

The SELECT trial (Lincoff and colleagues, 2023) followed more than 17,000 adults with heart disease and overweight but no diabetes, and found a 20% lower rate of major cardiovascular events on semaglutide.

To read the papers yourself, start with this PubMed search for Semaglutide.

How SEMA-1 compares

SEMA-1 20mg is easier to place once you see it next to the compounds it’s usually compared with. SEMA-1 acts on the GLP-1 receptor only and lasts about a week, the most studied compound in the group. The others:

• TIRZ-2 adds GIP receptor activity to GLP-1, a dual agonist with larger weight effects than semaglutide in trials
• RETA-3 hits GLP-1, GIP and glucagon receptors, the triple agonist with the biggest phase 2 numbers so far
• Survodutide is another GLP-1 and glucagon dual agonist, in phase 3 for obesity and the liver disease MASH
• CAG-4 works through amylin receptors instead of incretins, often studied next to or with semaglutide

The main difference between these compounds is which receptors they hit. Pick the one that matches the receptor question in your study, and use the others as comparisons. See them all on our GLP-1 peptides page.

Checking your SEMA-1 20mg

Peptira labels each SEMA-1 20mg vial with the compound and the amount. Labs that file batch documentation should ask our support team about the current batch before ordering.

If you verify incoming material yourself, the standard methods are HPLC for purity and mass spectrometry for identity. HPLC splits the sample and reports the main peak as a percentage, while mass spec confirms that peak has the right molecular weight.

Write the order date and the vial details into your lab notes. If a result looks odd later, you can tie it back to the exact material you used.

Reconstituting SEMA-1 20mg

The amount of liquid you add sets the concentration. For a vial holding 20mg:

• 1mL of bacteriostatic water gives 20mg/mL
• 2mL of bacteriostatic water gives 10mg/mL
• 3mL of bacteriostatic water gives 6.67mg/mL

Pick the volume that keeps your own calculations simple, then write the concentration and the mixing date on the label.

Most labs use sterile bacteriostatic water. We stock bacteriostatic water in 3mL, 10mL and 30mL sizes. Warm the sealed vial to room temperature, add the water slowly along the glass wall and swirl gently until it’s clear. Never shake it.

How to store SEMA-1 20mg

Store sealed vials of SEMA-1 20mg in the freezer at -20°C, out of direct light. Mixed solution goes in the fridge at 2 to 8°C and should be used within about 28 days.

Leave sealed vials sealed until you need them. Dry powder in a closed vial lasts far longer than solution, so there’s no reason to mix more than one at a time.

Choosing an SEMA-1 strength

• SEMA-1 10mg: $69.00, about $6.90 per mg
• SEMA-1 20mg (this page): $119.00, about $5.95 per mg

For longer projects a larger vial like SEMA-1 20mg means fewer vials to mix and fewer reorders.

Other GLP-1 peptides to look at

• RETA-3 30mg, a triple agonist
• TIRZ-2 30mg, a GIP/GLP-1 agonist
• Survodutide 10mg, a GLP-1/glucagon agonist
• CAG-4 10mg, an amylin analog
• MOTS-c 10mg, a mitochondrial peptide

Browse the full GLP-1 peptides and weight loss peptides range, see every vial on our research peptides page or head back to the Peptira home page.

Common questions about SEMA-1 20mg

How much is in the SEMA-1 20mg vial?

20mg of freeze-dried powder. The amount is printed on the label.

What is SEMA-1?

SEMA-1 is our catalog name for semaglutide. The vial holds semaglutide as freeze-dried powder.

Where can I buy SEMA-1 20mg?

Right here at Peptira. Add SEMA-1 20mg to the cart on this page and it ships free worldwide.

What do I mix SEMA-1 20mg with?

Sterile bacteriostatic water is the usual choice. The reconstitution section above shows the concentration for each volume.

How should I store it?

Keep sealed vials in the freezer at -20°C. Once mixed, refrigerate at 2 to 8°C and use within about 28 days.

Buy SEMA-1 20mg from Peptira

SEMA-1 20mg is in stock at $119.00. Add it to the cart, enter code PEPTIRA10 at checkout for 10% off, and shipping is free worldwide. Paying with crypto at checkout takes a little more off.

Need more for the same project? See the rest of our GLP-1 peptides and weight loss peptides, or go back to the Peptira home page.

For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.