MOTS-c 10mg

Our MOTS-c 10mg vial holds 10mg of lyophilized MOTS-c, a mitochondrial-derived peptide. It’s sold for laboratory research only.

The 10mg vial is the small size. For longer studies, MOTS-c 40mg costs less per milligram.

About MOTS-c

MOTS-c is a 16-amino-acid peptide coded not in the cell nucleus but in mitochondrial DNA, inside the gene for the 12S ribosomal RNA. Changhan Lee and colleagues in Pinchas Cohen’s lab at the University of Southern California described it in 2015.

It belongs to a small group of mitochondrial-derived peptides, alongside humanin, that act as signals from the mitochondria to the rest of the cell and body.

How MOTS-c acts in the lab

Most proteins are coded in the cell nucleus. MOTS-c is one of a handful of peptides coded in mitochondrial DNA instead. Its main target looks like the folate cycle, which feeds into AMPK activation and better glucose handling in muscle.

Under stress it can move into the nucleus and change gene expression. Circulating levels drop with age in both mice and people, which is why it’s studied in metabolism and aging.

MOTS-c 10mg product details

• Compound: MOTS-c
• CAS number: 1627580-64-6
• Molecular formula: C101H152N28O22S2
• Molar mass: 2,174.6 g/mol
• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
• Amount: 10mg per vial
• Form: lyophilized (freeze-dried) powder
• Label: compound name and amount printed on every unit
• SKU: MOTS-10
• Use: laboratory research only

MOTS-c research

The 2015 Cell Metabolism paper reported that MOTS-c prevented diet-induced obesity and insulin resistance in mice, working mainly through skeletal muscle.

Reynolds and colleagues reported in Nature Communications in 2021 that exercise raises MOTS-c levels in people, and that treating older mice with it improved their physical performance.

The primary literature is on PubMed, run by the US National Library of Medicine. Here’s a search for MOTS-c studies to start from.

How MOTS-c compares

Labs choosing MOTS-c 10mg usually weigh it against a few close relatives. MOTS-c is a 16-amino-acid peptide coded in mitochondrial DNA, studied for glucose use in muscle, while:

• AOD-9604 is hGH fragment 177-191 with an extra tyrosine, studied for fat breakdown without raising IGF-1
• 5-Amino-1MQ is a small molecule that blocks the enzyme NNMT inside fat cells

These are all studied for fat metabolism but act in different places: AOD-9604 and Fragment 176-191 on fat tissue from outside, 5-Amino-1MQ and MOTS-c from inside the cell. See them all on our weight loss peptides page.

MOTS-c 10mg reconstitution and concentration

Here’s the math for 10mg of powder:

• 1mL of bacteriostatic water gives 10mg/mL
• 2mL of bacteriostatic water gives 5mg/mL
• 3mL of bacteriostatic water gives 3.33mg/mL

Go with whichever number is easiest to work with in your protocol, and label the vial with the concentration and the date you mixed it.

Bacteriostatic water is the usual choice, and acetic acid helps with peptides that won’t dissolve in water alone. Add it slowly so it runs down the side of the vial, then swirl or roll until everything dissolves. Shaking can shear peptide chains. Skip it.

Storing MOTS-c 10mg

Freeze-dried MOTS-c 10mg handles room temperature fine during shipping, but for anything longer keep it in a freezer at -20°C, away from light. Once mixed, keep it in the fridge at 2 to 8°C and use it within about four weeks.

Running several vials at once? Our 10 vial kit case holds up to ten vials upright in separate wells under a clear lid, which keeps a fridge shelf tidy and the labels easy to read.

MOTS-c 10mg quality and handling

The vial label shows the compound and the amount. For anything your lab needs on file beyond that, email Peptira support with the product name before you place the order.

If you verify incoming material yourself, the standard methods are HPLC for purity and mass spectrometry for identity. HPLC splits the sample and reports the main peak as a percentage, while mass spec confirms that peak has the right molecular weight.

Write the order date and the vial details into your lab notes. If a result looks odd later, you can tie it back to the exact material you used.

MOTS-c sizes compared

• MOTS-c 10mg (this page): $49.00, about $4.90 per mg
• MOTS-c 40mg: $139.00, about $3.48 per mg

MOTS-c 10mg is the smallest size. It’s the one to start with for a pilot run or when you’re testing a new protocol.

Related to MOTS-c 10mg

• SLU-PP-332 BAM-15 Capsules, a capsule format
• SS-31 50mg, a mitochondrial peptide
• NAD+ 500mg, a coenzyme
• 5-Amino-1MQ 50mg, an NNMT inhibitor
• BAM-15 Capsules 50mg, a capsule format

Browse the full NAD+ and mitochondrial peptides, weight loss peptides and anti-aging peptides range, see every vial on our research peptides page or head back to the Peptira home page.

MOTS-c 10mg questions

How much is in the MOTS-c 10mg vial?

10mg of freeze-dried powder. The amount is printed on the label.

Where can I buy MOTS-c 10mg?

Right here at Peptira. Add MOTS-c 10mg to the cart on this page and it ships free worldwide.

What do I mix MOTS-c 10mg with?

Sterile bacteriostatic water is the usual choice. The reconstitution section above shows the concentration for each volume.

How should I store it?

Keep sealed vials in the freezer at -20°C. Once mixed, refrigerate at 2 to 8°C and use within about 28 days.

Can MOTS-c be used in people or animals?

No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.

Buy MOTS-c 10mg from Peptira

MOTS-c 10mg is in stock at $49.00. Add it to the cart, enter code PEPTIRA10 at checkout for 10% off, and shipping is free worldwide. Paying with crypto at checkout takes a little more off. Need water to mix it? Add bacteriostatic water to the same order.

Need more for the same project? See the rest of our NAD+ and mitochondrial peptides, weight loss peptides and anti-aging peptides, or go back to the Peptira home page.

For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.