NAD+ 500mg

NAD+ 500mg is a 500mg vial of NAD+, a coenzyme, supplied as freeze-dried powder. It’s for in-vitro and lab research only.

What is NAD+?

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell. It carries electrons in the reactions that turn food into ATP, and it’s used up by enzymes such as the sirtuins, PARPs and CD38.

Levels fall with age in several tissues in rodents and people, which is why NAD+ and its precursors, such as NMN and nicotinamide riboside, have become a major topic in aging research.

NAD+ mechanism of action

NAD+ shuttles electrons in glycolysis, the Krebs cycle and the mitochondrial chain, so it’s needed to turn food into ATP. It’s also used up by sirtuins, which regulate gene expression, and by PARPs, which repair DNA.

Because those enzymes consume it, NAD+ levels depend on constant recycling. Falling levels with age are linked to lower sirtuin activity, which is the basis for most NAD+ aging research.

NAD+ 500mg product details

• Compound: NAD+
• Also known as: nicotinamide adenine dinucleotide
• CAS number: 53-84-9
• Molecular formula: C21H27N7O14P2
• Molar mass: 663.4 g/mol
• Structure: dinucleotide coenzyme
• Amount: 500mg per vial
• Form: lyophilized (freeze-dried) powder
• Label: compound name and amount printed on every unit
• SKU: NAD-500
• Use: laboratory research only

Published NAD+ studies

Work from Shin-ichiro Imai’s lab at Washington University linked falling NAD+ to age-related decline in mice. In a small human trial published in Science in 2021, Yoshino and colleagues reported that the precursor NMN improved muscle insulin sensitivity in prediabetic women.

Most studies raise NAD+ with precursors such as NMN or nicotinamide riboside. Direct NAD+ work is a separate research question.

To read the papers yourself, start with this PubMed search for NAD+.

How NAD+ compares

Here’s how NAD+ 500mg fits among related compounds. NAD+ is the coenzyme behind cell energy and sirtuin activity, whose levels fall with age. By comparison:

• Epithalon is the tetrapeptide Ala-Glu-Asp-Gly, studied for telomerase activity
• Glutathione is the cell’s main antioxidant tripeptide
• MOTS-c is a 16-amino-acid peptide coded in mitochondrial DNA, studied for glucose use in muscle
• FOXO4-DRI is a D-amino-acid peptide built to push senescent cells into apoptosis

Aging research splits into a few processes, and each of these compounds targets one: telomeres, cell energy, oxidative stress, mitochondrial signaling or senescent cells. See them all on our anti-aging peptides page.

Checking your NAD+ 500mg

Peptira labels each NAD+ 500mg vial with the compound and the amount. Labs that file batch documentation should ask our support team about the current batch before ordering.

If you verify incoming material yourself, the standard methods are HPLC for purity and mass spectrometry for identity. HPLC splits the sample and reports the main peak as a percentage, while mass spec confirms that peak has the right molecular weight.

Write the order date and the vial details into your lab notes. If a result looks odd later, you can tie it back to the exact material you used.

Reconstituting NAD+ 500mg

Concentration is the amount in the vial divided by the volume of water you add. With 500mg of NAD+ in this vial:

• 3mL of bacteriostatic water gives 166.67mg/mL
• 5mL of bacteriostatic water gives 100mg/mL
• 10mL of bacteriostatic water gives 50mg/mL

Choose the volume that suits your measurements. Mark the vial with the concentration and date so nobody has to guess later.

Bacteriostatic water is the usual choice, and acetic acid helps with peptides that won’t dissolve in water alone. Add it slowly so it runs down the side of the vial, then swirl or roll until everything dissolves. Shaking only adds foam. Skip it.

NAD+ 500mg storage and shelf life

Store sealed vials of NAD+ 500mg in the freezer at -20°C, out of direct light. Mixed solution goes in the fridge at 2 to 8°C and should be used within about 28 days.

Let a frozen vial warm up to room temperature before you open it. Cold glass pulls moisture out of the air, and moisture is what degrades dry peptide.

Other NAD+ strengths

• NAD+ 500mg (this page): $59.00, about $0.12 per mg
• NAD+ 1000mg: $109.00, about $0.11 per mg

NAD+ 500mg is the entry size, handy when you only need a little or want to try NAD+ before committing to a bigger vial.

Often ordered with NAD+ 500mg

• SS-31 10mg, a mitochondrial peptide
• MOTS-c 40mg, a mitochondrial peptide
• 5-Amino-1MQ 50mg, an NNMT inhibitor
• AICAR 50mg, an AMPK activator
• BAM-15 Capsules 50mg, a capsule format

Browse the full NAD+ and mitochondrial peptides and anti-aging peptides range, see every vial on our research peptides page or head back to the Peptira home page.

NAD+ 500mg questions

How much is in the NAD+ 500mg vial?

500mg of freeze-dried powder. The amount is printed on the label.

Can NAD+ be used in people or animals?

No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.

Is NAD+ 500mg in stock?

Yes. This vial is in stock and ready to ship.

Where can I buy NAD+ 500mg?

Right here at Peptira. Add this vial to the cart on this page and it ships free worldwide.

What do I mix NAD+ 500mg with?

Sterile bacteriostatic water is the usual choice. The reconstitution section above shows the concentration for each volume.

Buy NAD+ 500mg from Peptira

This vial is in stock at $59.00. Add it to the cart, enter code PEPTIRA10 at checkout for 10% off, and shipping is free worldwide. Paying with crypto at checkout takes a little more off.

Need more for the same project? See the rest of our NAD+ and mitochondrial peptides and anti-aging peptides, or go back to the Peptira home page.

For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.