FOXO4-DRI 10mg

FOXO4-DRI 10mg is a 10mg vial of FOXO4-DRI, a D-retro-inverso peptide, supplied as freeze-dried powder. It’s intended for lab research only.

About FOXO4-DRI

FOXO4-DRI is a modified peptide that blocks the interaction between FOXO4 and p53. It’s built from D-amino acids in reverse order, which makes it resistant to enzymes.

It’s studied as a senolytic, meaning a compound that clears senescent cells.

How FOXO4-DRI acts in the lab

Senescent cells have stopped dividing but don’t die. In them, the FOXO4 protein holds p53 in the nucleus, which keeps p53 from triggering cell death.

FOXO4-DRI is a decoy that competes with FOXO4 for p53. With p53 released, it moves to the mitochondria and the senescent cell dies. Healthy cells barely use the FOXO4-p53 link, so they’re largely spared in the mouse studies.

FOXO4-DRI 10mg specifications

• Compound: FOXO4-DRI
• CAS number: 2460055-10-9
• Structure: D-retro-inverso peptide
• Amount: 10mg per vial
• Form: lyophilized (freeze-dried) powder
• Label: compound name and amount printed on every unit
• SKU: FOX-10
• Use: laboratory research only

FOXO4-DRI research

Baar and colleagues reported in Cell (2017) that FOXO4-DRI pushed senescent cells into apoptosis and restored fur density, fitness and kidney function in aged and fast-aging mice.

A 2020 study tested it on senescent Leydig cells in aged mice.

For the original studies, try this PubMed search from the National Library of Medicine.

FOXO4-DRI compared with similar compounds

FOXO4-DRI 10mg is easier to place once you see it next to the compounds it’s usually compared with. FOXO4-DRI is a D-amino-acid peptide built to push senescent cells into apoptosis. The others:

• Epithalon is the tetrapeptide Ala-Glu-Asp-Gly, studied for telomerase activity
• NAD+ is the coenzyme behind cell energy and sirtuin activity, whose levels fall with age
• Glutathione is the cell’s main antioxidant tripeptide
• MOTS-c is a 16-amino-acid peptide coded in mitochondrial DNA, studied for glucose use in muscle

Aging research splits into a few processes, and each of these compounds targets one: telomeres, cell energy, oxidative stress, mitochondrial signaling or senescent cells. See them all on our anti-aging peptides page.

Reconstituting FOXO4-DRI 10mg

Here’s the math for 10mg of powder:

• 1mL of bacteriostatic water gives 10mg/mL
• 2mL of bacteriostatic water gives 5mg/mL
• 3mL of bacteriostatic water gives 3.33mg/mL

Go with whichever number is easiest to work with in your protocol, and label the vial with the concentration and the date you mixed it.

Bacteriostatic water is the usual choice, and acetic acid helps with peptides that won’t dissolve in water alone. Add it slowly so it runs down the side of the vial, then swirl or roll until everything dissolves. Shaking can shear peptide chains. Skip it.

How to store FOXO4-DRI 10mg

The dry powder keeps best cold and dark. A freezer at -20°C is right for long-term storage. After reconstitution, store it in the fridge at 2 to 8°C and finish it within roughly four weeks.

Let a frozen vial warm up to room temperature before you open it. Cold glass pulls moisture out of the air, and moisture is what degrades dry peptide.

FOXO4-DRI 10mg quality and handling

Peptira labels each FOXO4-DRI 10mg vial with the compound and the amount. Labs that file batch documentation should ask our support team about the current batch before ordering.

If you verify incoming material yourself, the standard methods are HPLC for purity and mass spectrometry for identity. HPLC splits the sample and reports the main peak as a percentage, while mass spec confirms that peak has the right molecular weight.

Keep a record of which vial went into which experiment. Matching results to material is the simplest way to rule it out when an experiment doesn’t behave.

Planning a study with FOXO4-DRI 10mg

Start from the protocol. Total the amount every arm needs from the first time point to the last, divide by the 10mg in a vial and add a spare. It’s cheaper to order once than to wait on a second shipment halfway through.

Only reconstitute what you’ll use in the next few weeks. Sealed vials stay stable in the freezer, while a mixed vial should be finished within about 28 days.

If you order more than one vial, check that the batch numbers match before you start. Running a whole study on one batch removes one variable.

Often ordered with FOXO4-DRI 10mg

• SS-31 10mg, a mitochondrial peptide
• MOTS-c 40mg, a mitochondrial peptide
• NAD+ 1000mg, a coenzyme
• Cartalax 20mg, a bioregulator tripeptide
• Vilon 20mg, a dipeptide bioregulator

Browse the full anti-aging peptides range, see every vial on our research peptides page or head back to the Peptira home page.

FOXO4-DRI 10mg FAQ

How much is in the FOXO4-DRI 10mg vial?

10mg of freeze-dried powder. The amount is printed on the label.

Where can I buy FOXO4-DRI 10mg?

Right here at Peptira. Add FOXO4-DRI 10mg to the cart on this page and it ships free worldwide.

What do I mix FOXO4-DRI 10mg with?

Sterile bacteriostatic water is the usual choice. The reconstitution section above shows the concentration for each volume.

How should I store it?

Keep sealed vials in the freezer at -20°C. Once mixed, refrigerate at 2 to 8°C and use within about 28 days.

Can FOXO4-DRI be used in people or animals?

No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.

Buy FOXO4-DRI 10mg from Peptira

Order FOXO4-DRI 10mg now for $166.00. It’s in stock, code PEPTIRA10 takes 10% off at checkout, and we ship free to the US, Canada, Europe and Australia. Choose crypto at checkout for an extra discount. Need water to mix it? Add bacteriostatic water to the same order.

Need more for the same project? See the rest of our anti-aging peptides, or go back to the Peptira home page.

For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.