Cortagen 20mg

Cortagen 20mg is a 20mg vial of Cortagen, a synthetic bioregulator tetrapeptide, supplied as freeze-dried powder. It’s intended for lab research only.

Cortagen at a glance

Cortagen is a four-amino-acid peptide, Ala-Glu-Asp-Pro. It comes out of Vladimir Khavinson’s bioregulator program at the St. Petersburg Institute of Bioregulation and Gerontology, which proposed that very short peptides can enter the cell nucleus and change gene activity in a particular tissue.

The sequence was designed from the amino acid makeup of cortexin, a brain peptide extract, and the institute links it to the cerebral cortex and nerve tissue. It’s sold for lab research only.

How Cortagen works

Khavinson’s group proposes that short peptides like this one pass into the nucleus, bind specific DNA sequences or histone proteins and change how tightly chromatin is packed around certain genes. That would let a tissue-matched peptide turn up the genes that tissue needs.

Most of that evidence comes from cell cultures and aging animals studied by the same institute. Independent labs haven’t confirmed much of it yet, which is worth keeping in mind when you design controls.

Cortagen 20mg specifications

• Compound: Cortagen
• Also known as: Ala-Glu-Asp-Pro, AEDP
• Sequence: Ala-Glu-Asp-Pro
• Amount: 20mg per vial
• Form: lyophilized (freeze-dried) powder
• Label: compound name and amount printed on every unit
• SKU: CGEN-20
• Use: laboratory research only

Published Cortagen studies

Russian studies reported that Cortagen sped up nerve regrowth after sciatic nerve injury in rats and changed gene expression in heart and brain tissue samples.

As with the rest of the series, most of the data come from one research group, so treat the findings as early.

To read the papers yourself, start with this PubMed search for Cortagen.

Cortagen compared with similar compounds

Cortagen 20mg is easier to place once you see it next to the compounds it’s usually compared with. Cortagen is the tetrapeptide Ala-Glu-Asp-Pro, linked to the brain cortex and nerve tissue. The others:

• Pinealon is the tripeptide Glu-Asp-Arg, linked by its developers to brain tissue
• Cartalax is the tripeptide Ala-Glu-Asp, linked to cartilage and connective tissue

These all come from Vladimir Khavinson’s bioregulator program in St. Petersburg. Each short sequence is linked by its developers to one tissue, which is how labs pick between them. See them all on our peptide bioregulators page.

Cortagen 20mg reconstitution and concentration

Here’s the math for 20mg of powder:

• 1mL of bacteriostatic water gives 20mg/mL
• 2mL of bacteriostatic water gives 10mg/mL
• 3mL of bacteriostatic water gives 6.67mg/mL

Choose the volume that suits your measurements. Mark the vial with the concentration and date so nobody has to guess later.

Bacteriostatic water is the usual choice, and acetic acid helps with peptides that won’t dissolve in water alone. Add it slowly so it runs down the side of the vial, then swirl or roll until everything dissolves. Shaking can shear peptide chains. Skip it.

Cortagen 20mg storage and shelf life

Store sealed vials of Cortagen 20mg in the freezer at -20°C, out of direct light. Mixed solution goes in the fridge at 2 to 8°C and should be used within about 28 days.

Let a frozen vial warm up to room temperature before you open it. Cold glass pulls moisture out of the air, and moisture is what degrades dry peptide.

Checking your Cortagen 20mg

The vial label shows the compound and the amount. For anything your lab needs on file beyond that, email Peptira support with the product name before you place the order.

Labs that check material in-house normally confirm identity with mass spectrometry, which checks the molecular weight, and measure purity with HPLC, which separates the main compound from anything else in the sample.

If you run a long study, try to order everything you need at once and log it when it arrives. It removes one variable from your results.

How many Cortagen 20mg vials do you need?

Start from the protocol. Total the amount every arm needs from the first time point to the last, divide by the 20mg in a vial and add a spare. It’s cheaper to order once than to wait on a second shipment halfway through.

Mix one vial at a time and keep the rest sealed in the freezer. Dry powder keeps far longer than solution, so there’s no reason to reconstitute everything at the start.

Keep vials from one batch together in a study where you can. The batch number on the label ties each result back to the lab paperwork.

Often ordered with Cortagen 20mg

• Selank 10mg, a tuftsin analog
• Adamax 10mg, a modified Semax peptide
• DSIP 10mg, a neuropeptide
• PE-22-28 10mg, a TREK-1 blocking peptide
• Pinealon 10mg, a bioregulator peptide

Browse the full nootropic peptides range, see every vial on our research peptides page or head back to the Peptira home page.

Cortagen 20mg questions

How much is in the Cortagen 20mg vial?

20mg of freeze-dried powder. The amount is printed on the label.

What do I mix Cortagen 20mg with?

Sterile bacteriostatic water is the usual choice. The reconstitution section above shows the concentration for each volume.

How should I store it?

Keep sealed vials in the freezer at -20°C. Once mixed, refrigerate at 2 to 8°C and use within about 28 days.

Can Cortagen be used in people or animals?

No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.

Is Cortagen 20mg in stock?

Yes. Cortagen 20mg is in stock and ready to ship.

Order Cortagen 20mg today

Cortagen 20mg is in stock at $69.00. Add it to the cart, enter code PEPTIRA10 at checkout for 10% off, and shipping is free worldwide. Paying with crypto at checkout takes a little more off.

Need more for the same project? See the rest of our nootropic peptides, or go back to the Peptira home page.

For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.