PE-22-28 10mg

PE-22-28 10mg is a 10mg vial of PE-22-28, a seven-amino-acid spadin analog, supplied as freeze-dried powder. It’s for in-vitro and lab research only.

About PE-22-28

PE-22-28 is a seven-amino-acid peptide, Gly-Val-Ser-Trp-Gly-Leu-Arg, shortened from spadin. Spadin comes from the propeptide of sortilin, a protein involved in moving other proteins around inside neurons.

It was developed by Jean Mazella’s group in France as a more stable version of spadin. It’s a research compound only.

How PE-22-28 acts in the lab

PE-22-28 blocks TREK-1, a potassium channel that keeps neurons quiet. Mice lacking TREK-1 are resistant to depression-like behavior in standard tests, which is what made the channel a target.

In the mouse studies, blocking it also raised markers of new neuron formation in the hippocampus.

PE-22-28 10mg product details

• Compound: PE-22-28
• Also known as: spadin analog
• Sequence: Gly-Val-Ser-Trp-Gly-Leu-Arg
• Amount: 10mg per vial
• Form: lyophilized (freeze-dried) powder
• Label: compound name and amount printed on every unit
• SKU: PE2228-10
• Use: laboratory research only

Published PE-22-28 studies

Mazella and colleagues described spadin in PLoS Biology in 2010 as a blocker of the TREK-1 potassium channel with antidepressant-like effects in mice.

In 2017, Djillani and colleagues reported shorter analogs, including PE-22-28, that lasted longer and showed similar effects in mouse models within four days.

The primary literature is on PubMed, run by the US National Library of Medicine. Here’s a search for PE-22-28 studies to start from.

PE-22-28 compared with similar compounds

Labs choosing PE-22-28 10mg usually weigh it against a few close relatives. PE-22-28 is a short spadin analog that blocks the TREK-1 potassium channel, while:

• Semax is built on a fragment of ACTH and linked to BDNF in rodent studies
• Selank is built on tuftsin and studied for anxiety through the GABA system
• DSIP is a nine-amino-acid peptide first isolated from rabbits in deep sleep

These are studied for the brain but through very different routes: BDNF, the GABA system, sleep, a potassium channel and CNTF-style neurotrophic signaling. See them all on our nootropic peptides page.

Checking your PE-22-28 10mg

Every PE-22-28 10mg vial carries a printed label with the compound name and amount, so you always know what you’re holding. If your lab needs batch paperwork for its records, contact Peptira support before you order and ask what’s available for the current batch.

Labs that check material in-house normally confirm identity with mass spectrometry, which checks the molecular weight, and measure purity with HPLC, which separates the main compound from anything else in the sample.

Write the order date and the vial details into your lab notes. If a result looks odd later, you can tie it back to the exact material you used.

Reconstituting PE-22-28 10mg

Concentration is the amount in the vial divided by the volume of water you add. With 10mg of powder in this vial:

• 1mL of bacteriostatic water gives 10mg/mL
• 2mL of bacteriostatic water gives 5mg/mL
• 3mL of bacteriostatic water gives 3.33mg/mL

Go with whichever number is easiest to work with in your protocol, and label the vial with the concentration and the date you mixed it.

Use sterile bacteriostatic water, like our bacteriostatic water. Let the vial reach room temperature, run the water slowly down the inside of the glass, then roll the vial gently until the powder dissolves. Don’t shake it. Shaking can shear peptide chains.

Storing PE-22-28 10mg

The dry powder keeps best cold and dark. A freezer at -20°C is right for long-term storage. After reconstitution, store it in the fridge at 2 to 8°C and finish it within roughly four weeks.

Leave sealed vials sealed until you need them. Dry powder in a closed vial lasts far longer than solution, so there’s no reason to mix more than one at a time.

How many PE-22-28 10mg vials do you need?

Start from the protocol. Total the amount every arm needs from the first time point to the last, divide by the 10mg in a vial and add a spare. It’s cheaper to order once than to wait on a second shipment halfway through.

Mix one vial at a time and keep the rest sealed in the freezer. Dry powder keeps far longer than solution, so there’s no reason to reconstitute everything at the start.

If you order more than one vial, check that the batch numbers match before you start. Running a whole study on one batch removes one variable.

Other nootropic peptides to look at

• Pinealon 10mg, a bioregulator peptide
• Cortagen 20mg, a bioregulator peptide
• Semax 10mg, an ACTH(4-10) analog
• Adamax 10mg, a modified Semax peptide
• DSIP 10mg, a neuropeptide

Browse the full nootropic peptides range, see every vial on our research peptides page or head back to the Peptira home page.

PE-22-28 10mg questions

How much is in the PE-22-28 10mg vial?

10mg of freeze-dried powder. The amount is printed on the label.

What do I mix PE-22-28 10mg with?

Sterile bacteriostatic water is the usual choice. The reconstitution section above shows the concentration for each volume.

How should I store it?

Keep sealed vials in the freezer at -20°C. Once mixed, refrigerate at 2 to 8°C and use within about 28 days.

Can PE-22-28 be used in people or animals?

No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.

Is PE-22-28 10mg in stock?

Yes. PE-22-28 10mg is in stock and ready to ship.

Buy PE-22-28 10mg from Peptira

PE-22-28 10mg is in stock at $49.00. Add it to the cart, enter code PEPTIRA10 at checkout for 10% off, and shipping is free worldwide. Paying with crypto at checkout takes a little more off. Need water to mix it? Add bacteriostatic water to the same order.

Need more for the same project? See the rest of our nootropic peptides, or go back to the Peptira home page.

For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.