MOTS-c 40mg

MOTS-c 40mg is a 40mg vial of MOTS-c, a mitochondrial-derived peptide, supplied as freeze-dried powder. It’s for in-vitro and lab research only.

If you only need a little, MOTS-c 10mg is the smaller size.

MOTS-c at a glance

MOTS-c is a 16-amino-acid peptide coded not in the cell nucleus but in mitochondrial DNA, inside the gene for the 12S ribosomal RNA. Changhan Lee and colleagues in Pinchas Cohen’s lab at the University of Southern California described it in 2015.

It belongs to a small group of mitochondrial-derived peptides, alongside humanin, that act as signals from the mitochondria to the rest of the cell and body.

How MOTS-c acts in the lab

Most proteins are coded in the cell nucleus. MOTS-c is one of a handful of peptides coded in mitochondrial DNA instead. Its main target looks like the folate cycle, which feeds into AMPK activation and better glucose handling in muscle.

Under stress it can move into the nucleus and change gene expression. Circulating levels drop with age in both mice and people, which is why it’s studied in metabolism and aging.

MOTS-c 40mg technical data

• Compound: MOTS-c
• CAS number: 1627580-64-6
• Molecular formula: C101H152N28O22S2
• Molar mass: 2,174.6 g/mol
• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
• Amount: 40mg per vial
• Form: lyophilized (freeze-dried) powder
• Label: compound name and amount printed on every unit
• SKU: MOTS-40
• Use: laboratory research only

MOTS-c research

The 2015 Cell Metabolism paper reported that MOTS-c prevented diet-induced obesity and insulin resistance in mice, working mainly through skeletal muscle.

Reynolds and colleagues reported in Nature Communications in 2021 that exercise raises MOTS-c levels in people, and that treating older mice with it improved their physical performance.

To read the papers yourself, start with this PubMed search for MOTS-c.

How MOTS-c compares

Labs choosing MOTS-c 40mg usually weigh it against a few close relatives. MOTS-c is a 16-amino-acid peptide coded in mitochondrial DNA, studied for glucose use in muscle, while:

• AOD-9604 is hGH fragment 177-191 with an extra tyrosine, studied for fat breakdown without raising IGF-1
• 5-Amino-1MQ is a small molecule that blocks the enzyme NNMT inside fat cells

These are all studied for fat metabolism but act in different places: AOD-9604 and Fragment 176-191 on fat tissue from outside, 5-Amino-1MQ and MOTS-c from inside the cell. See them all on our weight loss peptides page.

Reconstituting MOTS-c 40mg

Concentration is the amount in the vial divided by the volume of water you add. With 40mg of powder in this vial:

• 2mL of bacteriostatic water gives 20mg/mL
• 3mL of bacteriostatic water gives 13.33mg/mL
• 5mL of bacteriostatic water gives 8mg/mL

Go with whichever number is easiest to work with in your protocol, and label the vial with the concentration and the date you mixed it.

Use sterile bacteriostatic water, like our bacteriostatic water. Let the vial reach room temperature, run the water slowly down the inside of the glass, then roll the vial gently until the powder dissolves. Don’t shake it. Shaking can shear peptide chains.

MOTS-c 40mg storage and shelf life

Freeze-dried MOTS-c 40mg handles room temperature fine during shipping, but for anything longer keep it in a freezer at -20°C, away from light. Once mixed, keep it in the fridge at 2 to 8°C and use it within about four weeks.

Let a frozen vial warm up to room temperature before you open it. Cold glass pulls moisture out of the air, and moisture is what degrades dry peptide.

MOTS-c 40mg quality and handling

The vial label shows the compound and the amount. For anything your lab needs on file beyond that, email Peptira support with the product name before you place the order.

Labs that check material in-house normally confirm identity with mass spectrometry, which checks the molecular weight, and measure purity with HPLC, which separates the main compound from anything else in the sample.

If you run a long study, try to order everything you need at once and log it when it arrives. It removes one variable from your results.

MOTS-c sizes compared

• MOTS-c 10mg: $49.00, about $4.90 per mg
• MOTS-c 40mg (this page): $139.00, about $3.48 per mg

For longer projects a larger vial like MOTS-c 40mg means fewer vials to mix and fewer reorders.

Related to MOTS-c 40mg

• AICAR 50mg, an AMPK activator
• SS-31 10mg, a mitochondrial peptide
• BAM-15 Capsules 50mg, a capsule format
• NAD+ 1000mg, a coenzyme
• 5-Amino-1MQ 50mg, an NNMT inhibitor

Browse the full NAD+ and mitochondrial peptides, weight loss peptides and anti-aging peptides range, see every vial on our research peptides page or head back to the Peptira home page.

Common questions about MOTS-c 40mg

How much is in the MOTS-c 40mg vial?

40mg of freeze-dried powder. The amount is printed on the label.

Where can I buy MOTS-c 40mg?

Right here at Peptira. Add MOTS-c 40mg to the cart on this page and it ships free worldwide.

What do I mix MOTS-c 40mg with?

Sterile bacteriostatic water is the usual choice. The reconstitution section above shows the concentration for each volume.

How should I store it?

Keep sealed vials in the freezer at -20°C. Once mixed, refrigerate at 2 to 8°C and use within about 28 days.

Can MOTS-c be used in people or animals?

No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.

Buy MOTS-c 40mg online

MOTS-c 40mg is in stock at $139.00. Add it to the cart, enter code PEPTIRA10 at checkout for 10% off, and shipping is free worldwide. Paying with crypto at checkout takes a little more off.

Need more for the same project? See the rest of our NAD+ and mitochondrial peptides, weight loss peptides and anti-aging peptides, or go back to the Peptira home page.

For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.